Established
Supported within its scope.
Sourced, matched to the right medicine and assessed population, approved and inside its review date. Only these findings inform a conclusion - and established does not mean universally applicable.
Synapptiq Governance
Intelligence that knows when to stop.
Before a finding reaches a payer discussion or executive report, its source, assessed population and limitations must hold up. Synapptiq separates established findings from unresolved questions and scenario estimates - and declines the questions its evidence cannot support.
See how evidence is reviewed01 / The principle
Intelligent restraint.
A persuasive sentence is not evidence. In pharmaceutical access, a confident answer built on the wrong population, an outdated price or an unsourced figure is worse than no answer at all.
Synapptiq's proprietary intelligence and governance systems sit between the technology and every finding you see. Technology may draft, capture and compare. It does not decide what is established.
Every finding must earn its place against a recorded source within its stated scope. What cannot be established is held in plain sight - never smoothed over - and scenario estimates stay separately labelled.
02 / Three evidence states
Every claim is checked.
Not every claim is shown.
Held
Not yet established.
Incomplete, unmatched or awaiting review. It stays visible as an open question, with its limitation stated, and outside every established conclusion.
Refused
Not supported.
Unsourced, contradicted or outside the assessed scope. It is declined rather than answered with an unsupported statement.
03 / How evidence is checked
Six checks between
the source and your decision.
01
Named and dated sources
A finding needs a recorded source and publication date so its basis can be examined. A statement that cannot point back to where it came from has no standing.
02
Medicine and assessed scope
Medicine, indication, population and comparator are fixed before a figure is used. A number from a different population is treated as a different claim, not a close enough one.
03
Human review of captured information
Language technology helps capture and compare published information; it never has the last word. Values are checked against their source and assessed population before they are accepted, and generated wording is not evidence.
04
Established, held or refused
Each claim is given one state - established, held or refused. Conflicting sources are recorded for review, not averaged into a conclusion.
05
Gaps stated, never filled
If a figure cannot be established, the answer says so. A gap stays visible rather than being filled with an estimate, and a missing month is never shown as zero.
06
Review dates
Each finding carries a review date. When it passes, the finding is withdrawn from this website until it is checked again.
04 / Restraint in practice
Follow one finding
from source to answer.
Source, medicine and population, finding, review and output - traced through a historical NICE TA393 finding. A held item can be inspected too, but it is never presented as a conclusion.
01 / Source
Alirocumab · NICE TA393
Historical appraisal example
Start with the original context.
NICE TA393 committee papers (Synapptiq endpoint record, citation verified)
- Source date
- 2016-06-22
- Captured
- 2026-10-25
A historical appraisal example, not a live processing record or current treatment advice.
Held finding: why it is not established
- Record / state
- TA393-REC-03 / Held
- Why it remains held
- Recorded but not yet anchored to a source quote
- Source / snapshot
- Synapptiq TA393 restriction records / HEOR-DECK-v9
- Captured / review by
- 2026-10-25 / 2027-10-25
The unresolved finding stays outside established conclusions; its recorded limitation explains why.
05 / Data governance
The same discipline
applies to your data.
Restraint is not only about what Synapptiq says. It governs who can see what, and what Synapptiq holds in the first place.
Separate website and application
This public website introduces Synapptiq. Customer use of the application is separate from sending a request through this site.
Authenticated, role-based access
Customers use Synapptiq through authenticated accounts, and what each person can see or change is set by their role.
Published, aggregate NHS information
NHS analysis uses published, aggregate sources. No patient-level NHS data is held.
Source-linked reports and exports
Executive reports and NHS analysis exports keep their source references, so the evidence travels with the conclusion.
Approved data and access statements
application
Authenticated access, role-based permissions, row-level access controls
Source: Synapptiq application · Reviewed 2026-10-27 · Review due 2027-10-27
aggregate published files
No patient-level NHS data held
Source: NHSBSA English Prescribing Dataset (EPD); NHSBSA Secondary Care Medicines Data (SCMD); Public Health Scotland prescribing data · Reviewed 2026-10-27 · Review due 2027-10-27
Confirmed by Pulsar Developments Ltd
Apart from essential cookies, the website collects nothing beyond the details entered in the request form
Source: Pulsar Developments Ltd · Reviewed 2026-10-31 · Review due 2027-10-31
Confirmed by Pulsar Developments Ltd
One customer's information is never visible to another customer
Source: Pulsar Developments Ltd · Reviewed 2026-10-31 · Review due 2027-10-31
Confirmed by Pulsar Developments Ltd
Source references are included in every download
Source: Pulsar Developments Ltd · Reviewed 2026-10-31 · Review due 2027-10-31
06 / Straight answers
What governance means here.
Can technology decide what is established?
No. Technology may draft, capture and compare information, but whether a finding is supported is decided by its recorded source, its scope, the evidence checks and human review - not by how confident generated wording sounds.
What happens when the evidence is incomplete?
The finding is held. It stays visible as an open question with its limitation recorded, outside established conclusions until the gap is resolved. A question the evidence cannot support is refused.
Are scenario estimates established findings?
No. Regulatory, access and launch scenario estimates combine recorded precedent with stated assumptions. Their uncertainty stays visible, and they are not forecasts or established findings.
Is the TA393 example current treatment advice?
No. NICE TA393 is a historical appraisal used to show how evidence is reviewed. Its review date controls whether it can appear here at all.
Does Synapptiq claim external certification?
No. We describe only the controls in place in the application. No external certification, regulatory endorsement or independent audit is claimed.
Connected, never unquestioned